Our lab mainly studies the pathogenesis of diseases caused by bacterial infection. In particular, we are interested in bacterial exotoxins, which promote the onset and development of infectious diseases by directly damaging host cells, impairing immune systems, and in various other ways. We apply both classic and edge-cutting experimental approaches to investigate the molecular, cellular, structural, and pathological mechanisms of how bacterial toxins and effector proteins target and interfere with essential host functions. Along the lines of basic research, we are also keen on translating our insights and knowledge toward developing new scientific tools and novel therapeutics. 

Our current research includes:

1. Characterization and regulation of important bacterial virulence factors.

2. Molecular mechanisms and pathology of bacteria-host interactions.

3. Host-bacteria interaction in complex physiological systems.

4. Development of tools & applications based on new theoretical advancements.