PUBLICATIONS
*Co-first author, #Corresponding author.（Update Date：2024-11-5）
2024
Li D*, Yang Q*, Luo J, Xu Y, Li J, Tao L# (2024) Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation. Cell Discovery 10, 112
Lv X*, Zhang Y*, Sun K, Yang Q, Luo J, Tao L#, Lu P# (2024) De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants. Nature Communications 15: 8521
Zheng Y*, Yang Q*, Luo J, Zhang Y, Li X, He L, Ma C, Tao L# (2024) Identification of a hemorrhagic determinant in P. sordellii TcsH and C. difficile TcdA. Microbiology Spectrum 12(6), e0035424
Zhou R*, He L*, Zhang J*, Zhang X, Li Y, Zhan X#, Tao L# (2024) Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin. Nature Communications 15: 1976
Zeng J#, Fang S, Guo J, Dong M, Tian G#, Tao L# (2024) Fight or flee, a vital choice for Clostridioides difficile. mLife 3(1): 14-20
2023
Zhou Y*, Zhan X*#, Luo J, Li D, Zhou R, Zhang J, Pan Z, Zhang Y, Jia T, Zhang X, Li Y, Tao L# (2023) Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin. Nature Communications 14: 8426
He A, Tian S, Kopper O, Horan D, Chen P, Bronson R, Sheng R, Wu H, Sui L, Zhou K, Tao L, Wu Q, Huang Y, Shen Z, Chen H, He X, Robling A, Jin R, Clever H, Xiang D#, Li Z#, Dong M# (2023) Targeted inhibition of Wnt signaling with a Clostridioides difficile fragment suppresses breast cancer tumor growth. PLOS Biology 21(11), e3002353
Hou Y, Xie T, He L, Tao L, Huang J (2023) Topological links in predicted protein complex structures reveal limitations in AlphaFold. Communications Biology 6: 1098
2022
Hui Y*#, Yao Y*, Qian Q, Luo J, Chen H, Qiao Z, Yu Y, Tao L#, Zhou N# (2022) Three-dimensional printing of soft hydrogel electronics. Nature Electronics 5, 893-903
Li D*, Zhou Y*, Tao L# (2022) Intestinal mucosa barrier and pathogenic bacterial infection. Progress in Physiological Sciences 53(6): 416-421
Liang G*, Lai C*, Yue Z, Zhang H, Li D, Chen Z, Lu X, Tao L, Subach F, Piatkevich K# (2022) Enhanced small green fluorescent proteins as a multi-sensing platform for biosensor development. Frontiers in Bioengineering and Biotechnology 10: 1039317.
Zhou Y*, Li D*, Li D, Chen A, He L, Luo J, Tao L#. (2022) LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin. Communications Biology 5: 906.
Yang Q, Zhou Y, He L, Zhang Y, and Tao L# (2022) Protocol for genome-wide CRISPR knockout screens of bacterial cytotoxins in HeLa cells. STAR Protocols 3:101595.
Li X*, He L*, Luo J, Zheng Y, Zhou Y, Li D, Zhang Y, Pan Z, Li Y, Tao L# (2022) Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions. Nature Communications 13:4331.
Luo J*, Yang Q*, Zhang X*, Zhang Y*, Wan L*, Zhan X, Zhou Y, He L, Li D, Jin D, Zhen Y, Huang J, Li Y#, Tao L# (2022) TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell 185(6): 980-994.
He L*, Huang X*, Zhang G, Yuan L, Shen E, Zhang L, Zhang X-H, Zhang T, Tao L#, Ju F# (2022) Distinctive signatures of pathogenic and antibiotic-resistant potentials in the hadal microbiome. Environmental Microbiome 17:19.
Wang L*, Li D*, Chen Z, He L, Wang X#, Tao L# (2022) An atypical case of monomicrobial Clostridioides difficile septicemia with no gastrointestinal manifestations. Frontiers in Cellular and Infection Microbiology 12:35.
2021
Zhou Y*, Li D*, Luo J*, Chen A, Li X, Pan Z, Wan L, He L, Li D, Li Y, Dong M, Tao L# (2021) Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin. Cell Research 31(8):935-938
Chen P*, Zeng J*, Liu Z, Thaker H, Wang S, Tian S, Zhang J, Tao L, Gutierrez C, Xing L, Gerhard R, Huang L, Dong M#, Jin R# (2021) Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Nature Communications 12, 3748.
Pan Z*, Zhang Y*, Luo J*, Li D, Zhou Y, He L, Yang Q, Dong M#, Tao L#. (2021) Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology. PLoS Pathogens 17(1):e1009197.
2020
Henkel D, Tatge H, Schottelndreider D, Tao L, Dong M, Gerhard R.(2020) Receptor binding domains of TcdB from Clostridioides difficile for chondroitin sulfate proteoglycan-4 and Frizzled proteins are functionally independent and additive. Toxins 12(12):736.
Shen E, Zhu K, Li D, Pan Z, Luo Y, Bian Q, He L, Song X, Zhen Y, Jin D, Tao L#. (2020) Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B. Communications Biology 3(1):347.
2019
Tao L*#, Tian S*, Zhang J*, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M#. (2019) Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nature Microbiology 4,1760–1769.
Chen P, Tao L, Liu Z, Dong M, Jin R. (2019) Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B. FEBS Journal 286, 874-881.
Before 2019
Chen P*, Tao L*, Wang T, Zhang J, He A, Lam K, Liu Z, He X, Perry K, Dong M, Jin R. (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science 360: 664-669.
Tian S, Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong M.(2018) Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. PLoS Biology 16, e2006951.
Zhang S, Lebreton F, Mansfield M.J., Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martı´nez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M. (2018) Identification of a botulinum neurotoxin-like toxin in a commensal strain of Enterococcus faecium. Cell Host & Microbe 23:169-176.
Tao L*, Peng L*, Berntsson RP-A, Park S, Yu F, Boone C, Stenmark P, Krupp J, Dong M. (2017) Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors. Nature Communications 8, 53.
Zhang S, Berntsson RP-A, Tepp W, Tao L, Johnson E, Stenmark P, Dong M. (2017) Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC. Nature Communications 8, 1637.
Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup BW, Miao J, He X, Hurdle GJ, Breault TD, Brass AL, Dong M. (2016) Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature 538:350-355.
Jana B, Tao L, Biswas I. (2016) Strain-Dependent Recognition of a Unique Degradation Motif by ClpXP in Streptococcus mutans. MSphere 1(6), e00287-16.
Tao L, Biswas I. (2015) Degradation of SsrA-tagged proteins in streptococci. Microbiology 161:884-894.
Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M. (2014) Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathogens 10: e1004177.
Tao L, Biswas I. (2013) ClpL is required for folding of CtsR in Streptococcus mutans. Journal of Bacteriology 195: 576-584.
Tao L, Chattoraj P, Biswas I. (2012) CtsR regulation in mcsAB deficient gram-positive bacteria. Journal of Bacteriology 194:1361-1368.
Wu X, Wang Y, Tao L#. (2011) Sulfhydryl compounds reduce Staphylococcus aureus biofilm formation by inhibiting PIA biosynthesis. FEMS Microbiology Letters 316: 44-50.
Tao L*, Wu X*, Sun B. (2010) Alternative sigma factor σH modulates prophage integration and excision in Staphylococcus aureus. PLoS Pathogens 6(5): e1000888.